Thymosin‐β4, and Human Vitronectin peptides Grafted to Collagen Tune Adhesion or VEGF Gene Expression in Human Cell Lines**

In order to improve collagen bioactivity for regenerative medicine approaches, thymosin-β4 (Tβ4P) and Human Vitronectin (HVP) derived peptides are grafted by thiol-ene Michael addition. Tβ4P HVP known exert a pro-angiogenic pro-adhesive activity respectively is involved in osteogenesis promotion. The ability of these increase cell adhesion angiogenesis properties assessed on human lines. particular, HVP-grafted increased osteoblast proliferation: after 24 h, both proliferation roughly showed 4-fold increase, if compared pristine collagen. Tβ4P-grafted promotes Vascular Endothelial Growth Factor (VEGF) gene expression vascular lines more than 7 times. These results suggest that may be an interesting biomaterial bone tissue regeneration, while useful